Which of the following is the most common cause of peptic ulcer disease (PUD) worldwide, including in Japan
Which of the following is the most common cause of peptic ulcer disease (PUD) worldwide, including in Japan?
A. Non-steroidal anti-inflammatory drugs (NSAIDs) use
B. Helicobacter pylori infection
C. Stress (e.g., major surgery, trauma)
D. Excessive alcohol consumption
Answer: B
Explanation: Helicobacter pylori infection is the leading cause of PUD globally, accounting for approximately 70%-90% of duodenal ulcers and 60%-80% of gastric ulcers. NSAID use is the second most common cause (A is incorrect). Stress and alcohol consumption are contributing factors but not the primary causes (C, D are incorrect).
