Which of the following is the first-line treatment for uncomplicated urinary tract infection (UTI) in women
Question : Which of the following is the first-line treatment for uncomplicated urinary tract infection (UTI) in women?
A. Ciprofloxacin
B. Trimethoprim-sulfamethoxazole (TMP-SMX)
C. Amoxicillin-clavulanate
D. Nitrofurantoin
Answer: D
Explanation: According to the 2023 Korean UTI Treatment Guidelines, nitrofurantoin has a high concentration in urine, good efficacy against Escherichia coli (the main pathogen of UTI), and low drug resistance, making it the first-line choice for uncomplicated UTI in women. TMP-SMX is not recommended as the first line due to high resistance rates in some regions; ciprofloxacin is used for complicated UTI; amoxicillin-clavulanate is an alternative. Thus, the correct answer is D.
