A 30-year-old female presents with pruritus, jaundice, and fatigue

A 30-year-old female presents with pruritus, jaundice, and fatigue

A 30-year-old female presents with pruritus, jaundice, and fatigue. Laboratory tests show elevated alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT), with normal transaminases. What is the most likely diagnosis?

A. Viral hepatitis

B. Non-alcoholic fatty liver disease

C. Primary biliary cholangitis (PBC)

D. Alcoholic hepatitis

E. Hepatocellular carcinoma

Answer: C

Explanation: Primary biliary cholangitis (formerly primary biliary cirrhosis) is an autoimmune disease affecting the intrahepatic bile ducts, characterized by pruritus, jaundice, elevated ALP and GGT (cholestatic pattern), and normal or slightly elevated transaminases. It is more common in middle-aged women.